...IMO of course...your line isn't coming to budge an inch at your indicator untill the hook has pricked. So by that, the lead can have no impact on the positioning of the hookhold.
As has been mentioned previously, with the line in the ridclip, will give a sudden jot to bury the hook further.
That said, the resistance of the line through the water as the fish tries to move off, will push the hook home. IMO if line is comming off your spool, no matter how loose your spool is, the hook is pushed right in, and it's the positioning of the initial prick that decides if its going to be a good hookhold or not.
The resistance of a fluro, or sinking braid through water is much higher, and IMO gives better hoiking potential.
It's all speculation on my behalf, and I'm not an expert on fluid dynamics, but I personally don't like running rigs with mono!